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The simplicity and scalability of the employed task also imply the utility of the zebrafish in high throughput drug screens.
And despite the utility of the zebrafish model for sussing out how microglia work, drug researchers are going to have to look elsewhere, says Verkhratsky.
This study has not only provided novel insights into the functional evolution of IGFBPs but also demonstrated the utility of the zebrafish model system in the study of IGFBP physiology.
In summary, here we highlight the utility of the zebrafish to expedite identifying unknown anti-inflammatory activities for existing drugs.
The work presented demonstrates the utility of the zebrafish model system for investigating the biological function of genes linked to human IBD.
Implications and future directions This study highlights the utility of the zebrafish system as an in vivo drug discovery platform to reposition existing drugs for anti-inflammatory applications.
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On the basis of effectors engaged by Ras and significant utilities of the zebrafish system, we envisage the mifepristone-inducible kras V12 liver cancer model being useful for high-throughput screens of anti-cancer drugs.
To test the utility of this zebrafish assay for natural product discovery, we screened crude methanolic extracts from over 80 East African medicinal plants.
Here we report the utility of using the zebrafish for this purpose.
The results from this study demonstrate the utility of the adult zebrafish as an excellent exercise model for advancing our knowledge on the basic mechanisms underlining the regulation of skeletal muscle mass.
In conclusion, we have identified an antibiotic from a natural product library with potent anti-inflammatory properties, and have established the utility of the mpx GFP transgenic zebrafish for high-throughput in vivo screens for novel inhibitors of neutrophil migration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com