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In particular, this approach allows one to evaluate a model's utility in the detection of large activity cliffs, a common occurrence within drug discovery.
Recent studies have also provided evidence that blood cell gene expression profiling might have utility in the detection of complex cardiovascular diseases such as atherosclerosis [10], coronary artery disease [11], [12], and arterial hypertension [13].
This paper describes the implementation, performance and validation of Messina compared to current commonly-used techniques, and demonstrates its utility in the detection of inconsistent differential expression in a case-control setting.
This biosensor thus has demonstrated its utility in the detection of H3-K9 methylatinns in vivo and potential value in preclinical drug development.
MFR, has clinical utility in the detection of dypiridamole non-responders and subclinical microvascular dysfunction that may be missed with traditional relative perfusion imaging [ 50].
Here, we confirm its utility in the detection of eight human microdeletion syndromes, including the more common WAGR, Smith-Magenis, and Potocki-Lupski syndromes with 100% sensitivity and 100% specificity.
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Development of small molecule probes that can detect eHsp90 in vivo may therefore have utility in the early detection of malignancy.
Moreover, this methodology may have important utility in the early detection of breast cancer associated mutations in NAF.
This result raises the possibility that RIFLE or AKIN criteria [ 8, 9], currently suggested as the standard methods for diagnosing AKI, may have limited utility in the early detection of AKI in the ED.
Although it is clear that total inhibin as a serum test has utility in the initial detection and prognosis of certain types of ovarian cancers, the biological function of inhibin in tumourigenesis is far from clear.
There is insufficient evidence at present to support the utility of thrombelastometry in the detection of post-traumatic coagulopathy.
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