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In addition to its utility for screening for genetic contributors to NDs, C. elegans is a useful pharmacological model for testing potential neuroprotective compounds.
Furthermore, it was found that the genomic prediction model using cpn60 UT gave similar results to whole-genome sequence alignments over a broad range of taxa, suggesting that this method may have general utility for screening isolates and predicting their taxonomic affiliations.
hPSCs also offer significant utility for screening prospective therapeutics.
Their origins are indicated in additional files 1 and 2. Many of the polypeptide sequences are highly conserved between species, and thus most protein and peptides provide utility for screening for autoantibody reactivity across species.
Although coupling droplets to MCE is an attractive prospect for HTS, most previous methods of interfacing have been developed for other applications (e.g., for two-dimensional separations or coupling to a sampling probe for chemical monitoring) and have limited proven utility for screening.
In addition, by exploiting a FACs-based assay for the detection of the VLP fluorescence we here originally describe, 18-4s cells would be of a great utility for screening new generations of antiviral compounds targeting late events of HIV-1 replication.
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* Full utility (1.00) assumed for screening states and 'Well' state; not varied in probabilistic sensitivity analysis.
We realized that the Bloomington stock center Df 'kit' that existed in 2002, when we began these experiments, was of limited utility for screens requiring dissection and analysis of embryos.
Results of this proof-of-principle study on clinical samples indicate clinical utility of multiplex ddPCR for screening for multiple EGFR mutations concurrently with an ultra-rare pretreatment mutation (T790M).
More sensitive assessments of pleural abnormalities can be done with computed tomography (CT) scans; however, cost, potentially unnecessary exposure to ionizing radiation, and risk of frequent false-positive findings reduce the utility of CT scans for screening low-risk individuals.
In order to explore the utility of the assay for screening inhibitors, the ATP competitor Staurosporine was used to inhibit enzyme activities using substrates Histone H1, PHAS-1 MBP.
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