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Conventional wisdom is nonetheless valuable, especially in its utility as a predictive indicator of the real trend it hides from.
Despite this conceptual framework for understanding diversity patterns, uncertainty about how the factors interact at a given location limits its utility as a predictive tool for how diversity may be expected to vary with, for example, depth at a particular location, or over a continental or global scale.
Decrement in heart rate was the only conventional hemodynamic variable that signified preload response but that also in retrospect, thus limiting its utility as a predictive tool.
These methods or correlation levels are outlined below in terms of the advantages of each along with its potential utility as a predictive tool.
Cereblon's central role as a target of lenalidomide and pomalidomide suggests potential utility as a predictive biomarker of response or resistance to IMiD therapy.
However, the low frequency of mutation in PIK3CA complicates its utility as a predictive marker for use in molecularly targeted medicine in clinical settings.
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We next analysed a series of 107 cases of primary breast cancer from the same patient population to determine whether analysis of CpG island methylation in CEBPδ has utility as a biomarker predictive of clinical relapse.
Furthermore, we demonstrate that methylation in CEBPδ is associated with metastasis and that methylation, when analysed with high-resolution, quantitative methodology may have utility as a biomarker predictive of future metastatic relapse.
Our data imply that CEBPδ may have utility as a biomarker predictive of relapse and metastasis and thus in the identification of patients who may derive greater benefit from adjuvant treatment.
In addition, group 2 included all individuals with high eIF4E and p4E-BP1 (i.e. individuals likely to have high eIF4E activity by all measures) reflecting the fact that z successfully takes account of both eIF4E and p4E-BP1, thereby supporting its utility as a potential predictive marker.
The clinical utility of ER as a predictive biomarker to identify breast cancer patients that will benefit from hormonal therapy is well established [ 14].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com