However, the predictive utility attributable to nx is exceedingly small (Table 3, lower section).
As with the disease-specific PANSS by adverse-effect method, utility attributable to long-acting risperidone treatment increased at endpoint but by a smaller degree, 0.0285 units (95% confidence interval: 0.039 0.017).
The QoL (preference) weight was then calculated as the net difference between these two scores, and could be described as the utility loss attributable to stroke.
The development of these health states is described further in a direct preference elicitation study designed to identify utility values attributable to each health state.
However, regression analysis demonstrated that utility worsens with increasing disease severity, and therefore, that the estimated reduction in utility was at least partially attributable to RVVC itself.
For repeat occurrences of a particular type of fracture, the model used the first-year utility multiplier in the year of the repeat fracture and a specified proportion (25% by default) of the disutility attributable to the subsequent utility multiplier from the previous fracture.
Tables 3 and 4 summarise occupation-attributable cancer registrations for the mining, manufacturing and utilities industries that are responsible for at least 10 attributable cancers a year, by carcinogen/exposure circumstance and by cancer site, ordered by industries associated with the most attributable cancers and the exposures (Table 3) and cancer sites (Table 4) involved.
Previous authors have published simulation studies looking at the number of hypothetical low risk variants that would be necessary to achieve various benchmarks of population attributable risk and predictive utility (Yang et al. 2003, 2005; Janssens et al. 2007).
For the measurement of QALYs, each state in the Markov model is assigned a utility score and the total QALYs attributable to treatment depend on the number of patients in each state over the time horizon of the model.
This is likely attributable to the noise around EQ-5D utilities, corroborated by the larger standard deviation around EQ-5D utilities, which may reflect natural variations in health status not related to OAB.
