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Utilising this model, we performed the virtual screening of Maybridge chemical library and the identified hits were then subsequently filtered based on the Naïve Bayesian classification model.
Utilising this model, we provided scheduled access to a solid high fat palatable diet (HFD) for a 2-h period each day, without imposed caloric restriction during the remainder of the day, a manipulation that resulted in consumption of large, binge-type meals in both rats and mice (Bake, Duncan, Morgan, & Mercer, 2013).
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The vast majority of existing studies utilising this model have examined the reinstatement of a previously extinguished operant response in order to assess drug-seeking (i.e. relapse-like) behaviour [11].
Utilising this model, the used force is adapted to each specimen's resistance.
Therefore, we utilised this model and modulated galectin-3 levels using modified citrus pectin (MCP), a derivative of pectin; which is a soluble dietary fibre found in the peel and pulp of citrus fruits [20].
Our ultimate goal is to utilise this model system for personalised treatment for PDAC patients in a short time frame.
It would be interesting to utilise this model to investigate the effects of these other mediators on the CaSR and on FGF9 mediated proliferation.
Recently, Andersson and colleagues utilised this model to carry out a high-throughput screen for drugs that enhance β-cell regeneration (Andersson et al., 2012).
In order to utilise the model, we first had to transform our observed bioaccessibility data into bioavailability values as follows.
As our experimental basis, we utilised this commonly used endotoxicosis model.
We utilised a model of warm in vitro hypoxia and H R that we have described previously [14].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com