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Utilising the parameter estimates from analysis of the pilot study, a statistically efficient [ 26] fractional factorial design of 50 different choice combinations, segmented into 2 blocks of 25 choices was created using NGENE (http://www.choice-metrics.com) (design d-error of 0.024).
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The coefficient of diffusion was ascertained for the Pt(IV) and Pt II) drugs through the MCL model utilising the parameters of mass transfer coefficient (k), MCL thickness (xM), diffusivity in the medium (D1) and initial drug concentration (CD).
Results of the theoretical investigation utilising the kinetic parameters found by experiment indicated reasonably good agreement between theory and experiment.
As such, the technique involves on-line design of a model-based filter, utilising the plant parameters identified as part of the adaptive control process.
Images will be acquired with an axial 3D, phase cycled, fully balanced, steady-state coherent imaging pulse sequence (3D FIESTA-C), utilising the following parameters: repetition time ~11.8 ms, echo time 1.0 ms, flip angle 60 degrees, resolution 0.195 × 0.195, 512 × 384 matrix, slice thickness 1 mm and a scanning time ~16 minutes.
The evolutionary distances were calculated utilising the Kimura-2 parameter method (Kimura 1980) and are in the units of the number of base replacements per location.
Numerical strategies were developed to determine the relevant material parameters, utilising the monotonic, cyclic, relaxation and creep test data of waspaloy at 650 °C.
These reactive models utilise the hydrodynamic parameters determined using the ACUAINTRUSION TRANSPORT software and fit the chloride breakthrough curves perfectly.
Utilising the equations derived above and the specific parameters for auxin allows us to quantify the extent that this mechanism could indeed be relevant.
Utilising these parameters whilst varying the substrate concentration gave classical Michaelis Menten kinetics (Fig. 3A), with a Km of 28.7 ± 7.4 μM for phosphorylation of the YA substrate by C-Src, which compares favourably with the previously observed Km of 33 μM for C-Src phosphorylating the free AEEEIYGEF peptide [31].
All models were developed using scikit-learn [23], using default parameters unless otherwise indicated, and inductive conformal predictors were derived utilising the nonconformist package [24].
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