All assumed the peripheral sampling site concentration could be described by contributions from surrounding tissues and utilised tissue-specific concentration-time profiles reported from the full-PBPK model within the Simcyp Simulator.
We generated DEC1 antibody and constructed tissue microarrays (TMAs) utilising tissue specimens from Henan, a high-risk region for oesophageal SCC, to investigate the importance of DEC1 expression in this cancer.
Restricting gene expression to specific cell subsets utilising tissue-specific promoter driven retroviral vectors is a challenge.
The discovery of novel anticancer therapies now preferentially involves the use of models which have greater resemblance to clinical disease [33 35], primarily by utilising tissues resected from patients.
Recent studies utilising tissue-specific deletion of Pten in liver, adipose and muscle have shown that these organs make important contributions to the glucose homeostasis of the animal and clearly establish Pten as a negative regulator of insulin signalling in vivo [ 9– 11].
Rapid prototyping (RP) techniques have been utilised by tissue engineers to produce three-dimensional (3D) porous scaffolds.
A rapid-acquisition dispersive-type NIR Raman system was utilised for tissue Raman spectroscopic measurements at 785 nm laser excitation.
There is also limited knowledge regarding patients' preferences for receiving information about research studies that have utilised their tissue samples.
We utilised a tissue microarray (TMA) of 530 CaP cores from 168 individual patients and stained for both mir143 and ERK5.
These studies utilise holistic tissue monitoring that includes tissue chemistry analysis, tissue oxygenation, and perfusion measurement using techniques described in earlier sections.
