Sentence examples for utilised mouse models of from inspiring English sources

Our finding that three commonly utilised mouse models of breast cancer are characterised by distinct tyrosine phosphorylation based signalling networks provides important insights into mechanisms of mammary tumour development and progression.

While this diversity has been suggested to contribute to these differential outcomes, recent work utilising mouse models of JBTS has indicated that there may be underlying mechanisms that modify the disease phenotype, even when the exact Cep290 mutation site is conserved.

For the current study we therefore utilised a mouse model of moderate pulmonary inflammation and barrier permeability induced by a low dose intratracheal LPS administration.

Given that the bleomycin-induced model of SSc is an important tool in understanding the pathogenesis of fibrotic skin changes, we investigated the susceptibility and intensity of dermal fibrosis observed in mouse skin of three widely utilised mouse strains of both genders.

In the recent study of Ogawa et al. [ 42] utilising a mouse model of asthma, it was observed that mice challenged with house dust mite allergen exhibited an increase in NGF that was primarily expressed in bronchial epithelium and was positively correlated with airway hyperresponsiveness and substance P-positive nerve fibers.

This lack of knowledge hinders research utilising these cells in vitro, used to delineate the pathology in mouse models of inflammatory joint disease.

There are now mouse models of Parkinson's.

By utilising a regulatory transgenic reporter mouse model of human CYP3A4, Charles and colleagues demonstrated that the presence of tumour resulted in down-regulation of the CYP3A4, which correlated with a systemic acute phase response.

In terms of biological plausibility, animal studies utilising allergic mouse models showed that statins have anti-inflammatory, anti-remodelling and immunomodulatory effects that attenuate airway hyper-reactivity and improve lung function.

In this study, we sought to utilise this route of immunization with CII to interfere with the development and evolution of CCIA disease in the DBA/1-TCR-β Tg mouse model of RA.

We utilised a mouse model to investigate how trisomy 21 might affect gene regulatory networks and adult neurogenesis.