In vivo, utilising a mouse model grafted with prostate carcinoma, significant tumour suppression was achieved using PEGylated complexes without marked toxicity or undesirable immunological response, this was accompanied by a simultaneous reduction in target mRNA levels.
In addition, in a study utilising a mouse model in which hyperproliferation/hyperplasia of the colon was induced, cyclin D1 protein levels measured in tissue extracts were significantly enhanced (Sellin et al, 2001).
Also, recent work utilising a mouse model has shown that ACVs do in fact remain efficacious against a group of strains which possess variant alleles, provided that the ACV is of sufficient potency [ 21].
In the recent study of Ogawa et al. [ 42] utilising a mouse model of asthma, it was observed that mice challenged with house dust mite allergen exhibited an increase in NGF that was primarily expressed in bronchial epithelium and was positively correlated with airway hyperresponsiveness and substance P-positive nerve fibers.
Thus, utilising a syngeneic mouse model, we investigated the remodelling of GEP of neoplastic and normal tissues induced by systemic administration of DHA.
"Blocking tumor necrosis factor in a mouse model improves asthma," Dr. Remick said.
In this paper, we have utilised a recently generated mouse model for ACP and carried out an unbiased molecular screen demonstrating the de-regulation of numerous genes and signalling pathways with tumorigenic potential in both mouse and human ACP.
In order to explore this we have utilised an APOE 'humanised' mouse model lacking the mouse APOE gene with human APOEε3 or ε4 knocked in.
We utilised two mouse models, each manifesting distinct AD-related pathologies: the K3 tau transgenic model, which develops NFTs [ 21, 22]; and the APP/PS1 transgenic model, which develops amyloid plaques [ 23].
