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This study utilised a model that was designed with the objective of isolating the maternal-offspring separation and social reorganisation occurring at weaning time, in order to characterise the weaning response without the associated stress resulting from simultaneous housing and novel handling.
Here we utilised a model that recapitulates pre-malignant phase of basal-like breast carcinogenesis [ 34] and found significant alterations in DNA methylation and chromatin modification patterns that were associated with dysregulation of cancer-associated genes and pathways; specifically, genes and loci targeted by, EZH2/polycomb, MYC, AHR and the p53 pathway.
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In order to determine the role of activated Kras in metastasis, we utilised an orthotopic model that revealed a significant inhibition of metastasis upon selective silencing of KrasG12D (Table 1).
We utilised a model of warm in vitro hypoxia and H R that we have described previously [14].
To determine whether NS-398 possessed any inhibitory effects on the development of liver metastasis, we utilised an animal model that generates metastasis by the injection of MC-26 cells into the splenic subcapsule.
All of these previous in vivo studies with PEDF have utilised a clinically relevant orthotopic model that allows an evaluation of both primary and secondary tumour progression.
To determine the effect of combining GSI with radiation in vivo, we utilised a xenograft model.
In this paper we describe our experiences of utilising Cloud Computing and outline a governance model that could be supported for the storage and management of BIM.
To further investigate possible cytoprotective properties of MMF and DMF, we used an in vitro model that utilised the toxic substances H2O2 as oxygen radical donor and SNP as nitric oxide (NO) donor on CG4 OPC.
A backward step-wise approach using the default 'enter' method in SPSS was utilised, removing variables from the model that were non-significant until only variables with a p <0.05 remained in the model.
Last in this series of evaluations is the performance-wise comparison of ChER with MetaboliNER [23], a tool based on a CRF model that utilised the Chemical Entities of Biological Interest (ChEBI) [26] and Human Metabolome (HMDB) [27] databases as dictionaries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com