The prevention study utilised methodologies previously described (Grubbs et al, 1985; Parikh et al, 2005) to test the ability of AFPep, Tam, or the combination of AFPep and Tam to prevent MNU-induced breast cancers in rats.
We therefore utilised methodology from a previous military combat study, aimed at identifying patients in whom REBOA may have been utilised.
LQR is an increasingly utilised methodology in health services research, for example in the development and evaluation of complex health interventions or to study transitions in recovery or long term illness.
Researchers may utilise other methodologies including other MCDM methodologies and may compare the results.
These employ very low doses of experimental agent and utilise new methodologies and technologies to study pharmacokinetics at a dose that minimises any risk of toxicity (Kummar and Doroshow, 2011).
We utilised two methodologies to assess the cost of the MDMs.
The resource commitment required to utilise this methodology has made it unworkable within a number of institutions, particularly where class sizes are large [ 1, 18].
HOST will utilise mixed methodology to investigate the extent to which individual personality affects the success of CISC training and the impact of CISC on QoL.
Future work in the K/BxN mice might utilise this methodology to compare and improve the characterisation of FLS isolated from inflamed synovium.
A distinction can be drawn between PRO-AEs in specified populations (either pre- or post-launch, with both utilising similar methodologies) and those in patient populations not prespecified, which demand different methodologies.
Further studies and/or meta-analyses of studies utilising different methodologies, and eventually transgenerational follow-up, need to be performed in order to address some initial concerns in larger representative cohorts.
