It is usually very difficult to assess the effectiveness of the RCM at its inception, when data is inadequate or when it is implemented on a large population of assets, especially when most of them are small in size as in the distribution systems.
Moreover, residual renal function is usually variable, difficult to assess and rarely considered when dosing, despite its relevant contribution to antibiotic CL in patients undergoing CRRT that has been described for meropenem and piperacillin among others [ 26, 29, 32].
However, it is usually difficult to preclinically assess the effectiveness of targeted therapies, and apparently promising compounds sometimes fail in clinical trials.
However, the detailed temporal dynamics of cavities and their lifetime occupancy rates and survival are not usually known which makes it difficult to assess the actual significance and full impact of primary cavity-breeders.
Division Two of the County Championship is always difficult to assess because it usually goes down to the wire.
As the laparoscopic D-light system is usually not used for open surgery, it was difficult to assess the macroscopic fluorescence adequately.
The full extent of the industrial R&D in biophotonics is difficult to assess as start-up companies usually protect their IP during the early phases of development.
Completion of sedation is sometimes difficult to assess with patient presenting Alzheimer disease, but usually, when neuromotor disorders cease (teeth grinding, hands tension), induction is completed.
The initial virus incubation stage is difficult to assess before an individual is symptomatic since it usually occurs without clinical manifestations.
The effects of retention in utero before birth are more difficult to assess as the time of fetal death is usually unknown.
