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HDAC1 inhibition by MS-275 in vitro has usually been demonstrated using recombinant HDAC1 enzymes (Hu et al, 2003).
RRL was first and has usually been demonstrated through restriction site-associated DNA (RAD) tagging and NGS of RAD tags [ 18, 19].
This two-locus hypothesis is more probable than the single-locus one, because postzygotic incompatibilities have usually been demonstrated to be caused by epistatic interactions between at least two genes.
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The principle of surface wettability can usually be demonstrated by the Young equation, as follows (Wang et al. 2015): cos theta = frac{{gamma_{text{sv}} - gamma_{text{sl}} }}{{gamma_{text{lv}} }} (3)where γsv, γsl and γlv are the interfacial free energy of solid/vapor, solid/liquid, and liquid/vapor, respectively; and θ is the contact angle.
In AL amyloidosis, the presence of a monoclonal immunoglobulin, M protein, can usually be demonstrated in serum or urine samples.
Many benign conditions which may affect surgical procedure, such as biliary tract stones or abdominal aortic aneurysms, can usually be demonstrated by abdominal ultrasonography (US).
In the various studies where the prevention of hip fracture with treatment, usually with bisphosphonates, has been demonstrated, the study population has tended to be relatively young (generally around 70) and, by selection, usually with quite severe osteoporosis as shown by the presence of spinal fractures.
Molecular biomarkers assayed in tumour pretreatment (usually diagnostic) endoscopic biopsies have been demonstrated to be of value for prediction of response to both cytotoxic and targeted therapies in a number of human cancers including gastro-oesophageal adenocarcinomas (Bang et al, 2010; Sun et al, 2011).
Even when a statistically significant benefit on OS has been demonstrated, modeling is usually needed to predict the tail of the survival curves in order to estimate the mean gain in life expectancy.
Furthermore, HOXA4 hypermethylation has been demonstrated to be usually associated with the progression of CML to blast phase and play an important role in the development of leukemia [ 7].
But a technical product usually has to be demonstrated to customers; distributors with few product lines are often best able to provide that concentrated technical assistance.
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CEO of Professional Science Editing for Scientists @ prosciediting.com