Exact(2)
The usual endpoints that have been used to determine the fetal 'safety' of late-trimester chemotherapy include congenital malformations, developmental milestones and pediatric tumor rate.
Here, we agree with the recent statement by the European Medicines Agency (EMA) 28 that "it is not expected to be feasible to demonstrate superiority for the new agent over BAT based on the usual endpoints that would be applied to each type of infection".
Similar(58)
Transit planners decided instead to cut off the route at 42nd Street, 11 blocks shy of its usual endpoint.
Due to the mechanism of action of new drugs, cytostatic more than cytotoxic at least in principle, the usual endpoint of phase II trials, objective response rate, is now often replaced by alternative event-related endpoints, such as progression-free survival or progression-free rate at a fixed time-point.
For the CV, the EP is detected before the usual endpoint time.
It may be useful in such studies, in addition to the usual endpoint of the time to first episode, to include end points which take into account the total number of clinical episodes experienced per child.
Reduction of the total number of episodes (i.e., the total effect) is the usual endpoint of public health interest (8, 19).
(2.7) Also, if at least one of T or S has the approximate endpoint property, then T and S have the usual approximate endpoint property.
If T and S have the usual approximate endpoint property, by Corollary 5.5, we conclude that T and S have a unique endpoint (x_{0}).
By using the separation theorem obtained in Section 3 and the results in Section 4, we prove that two generalized weak contraction multi-valued mappings have a unique common endpoint if and only if either they have the usual approximate endpoint property or they have the common approximate strict fixed point property.
Then, by using this and the related results, we prove that two generalized weak contraction multi-valued mappings have a unique common endpoint if and only if either they have the usual approximate endpoint property or they have the common approximate strict fixed point property.
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