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That link paved the way for using yeast as a model for studying various human genetic diseases involving problems with protein transport in cells – for example, forms of diabetes and haemophilia.
Starting in 1997, Jansen worked to elucidate DNA-repair mechanisms using yeast as a model organism.
This is the first evidence of enantiopure (R -3-HB synthesis using yeast as a pR -3-HBon host and glucose as a caR -3-HBurce.
Using yeast as a tool to study human disease and basic biology is quite common, but some may argue its time is limited, what with the completion of the human genome and other genomes of organisms of closer ancestry.
Key principles of GPCR signaling have been unraveled using yeast as a model system.
Using yeast as a heterologous system for apoptosis evaluation, the metacaspases AtMCP1b and AtMCP2b from the plant Arabidopsis thaliana were also found to be involved in apoptosis induced by H2O2 [40].
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Using yeast as an experimental model, the molecular mechanisms underlying ubiquitination-mediated membrane trafficking were intensively investigated [3], [9], [10].
The answers to these questions have wide ranging implications for laboratories using yeast as an expression and screening platform for recombinant DNA libraries.
Moreover, the general conservation of both mitochondrial genes and pathways between human and yeast allows us to use yeast as a model for some diseases [ 87].
To obtain more insight in the biogenesis of COX in a living cell, we used yeast as a model organism to design a way to pulse label holo-COX with green fluorescent protein (GFP).
Here, we use yeast as a model to systematically analyse the intracellular effect of expressing 21 variants of the amyloid-ß-peptide, engineered to cover a continuous range of intrinsic aggregation propensities.
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