Most studies addressing treatment of vitamin D deficiency in dialysis patients use weekly doses of 50.000 IU ergocalciferol or cholecalciferol, as recommended by KDOQI for the general population and for patients with CKD stage 3 to 4 [ 1, 5].
One of the first randomised vitamin A trials used small weekly doses of vitamin A instead of a high-dose supplement and that study found the strongest beneficial effect of vitamin A supplementation [ 14].
60, 61 A Phase III study was conducted using a weekly dose of 1 mg/kg in 39 patients, for 24 weeks, confirming the Phase II study results, with improvement in overall resistance measured by the 12-minute walk test and stair climbing, reduced GAG excretion in the urine, and good tolerability.
Most studies have used three times weekly doses of 150 U kg−1, with a dose increase to 300 U kg−1 in non-responders (Cascinu et al, 1994; Henry and Abels, 1994).
To reduce the hematologic toxicity, we modified the TPS regimen using weekly docetaxel at a dose of 30 mg/m.
Another group was subjected to four weekly doses of 1.2 Gy of γ-irradiation [ 30] and used for the tumor study (see timeline in Figure 9).
William's doctor prescribed weekly doses of prednisone in pill form, not weekly injections of prednisone.
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using a total volume of 20 µl per dose in the lower flank, with three doses of PBS or γ-spz at weekly intervals, in some experiments with two weekly doses of 200 × 10, or one dose of 600 × 10 γ-spz, or i.v. by retro-orbital injection with 3-weekly doses of PBS or 50 × 10 γ-spz (100 µl per dose).
Each maintenance course consisted of four weekly doses of rituximab.
