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To ensure the robustness of the result, we performed 1000 independent bootstrap experiments and also repeated the analysis using varying thresholds of "high frequency" (90% and 85%) and still observed similar results (Supplementary File S2).
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A next step will be to use varying thresholds, dependent on the relative degree of perturbation promiscuity.
It is difficult to suggest a threshold level for pleural fluid NT-pro-BNP since the studies used varying threshold levels.
Varying thresholds of weight loss have been used, the most common being >5% (Fox et al, 2009; Knoll et al, 2008; Maltoni et al, 2001) and >10% (Gordon et al, 2005; Skipworth et al, 2010; Zhang et al, 2007).
The receiver operating characteristics (ROCs) are shown in Figure 6, which are obtained by evaluating MDP and FAR pairs using varying values of the detection threshold for dB and 3 dB SNRs.
(I now know how to track the varying threshold of Andy Capper's tolerance for the sound of my voice).
We used varying p value thresholds for probe selection due to the absence of probes significant at the 0.05 level.
We anticipate the use of varying thresholds for different experiments for optimal results.
When sparring, use varying combinations.
Unlike a traditional ROC plot used to explore the effect of varying thresholds (cut-points) on TPR and FPR in a single study, each data point in the SROC plot represents a separate study the meta-analysis.
Lastly, we used summary ROC curves to take into account the impact of varying thresholds and also the interdependence of sensitivity and specificity.
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