Sentence examples for using transgenic knockout from inspiring English sources

Objective: To test the possibility of using transgenic knockout mice in the study of endometriosis and to investigate specific immunologic aspects of the disease.

To determine the transcription factors necessary for TNFα production in response to dsDNA, we used transgenic knockout mouse embryonic fibroblasts (MEFs).

Here we review mouse studies aimed at understanding TNF physiologic functions using transgenic and knockout models, and we discuss additional mouse models that may be helpful in the future.

Our phenotype data was obtained from previously published mouse phenotyping studies using transgenic or knockout mice.

Studies using transgenic and knockout mice continue to provide information on specific genes that may play a role in OA progress [ 95].

By using transgenic and knockout mouse models stroma-cell derived S100A4 was shown to have a causal role in tumor progression [ 10- 15].

Further functional characterization of these genes using transgenic overexpression, knockout strategies, and knockdown strategies may help elucidate the molecular mechanisms controlling sex determination and gonadal development in teleost.

In a recent pair of reports in Nature, experiments using transgenic and knockout mice clearly demonstrated that the pericytes surrounding the brain blood vessels play an intimate role in the formation and maintenance of BBB integrity, challenging the conventional view that astroglial cells play the major role in regulating the BBB [ 21, 22].

Studies in the cuprizone model using transgenic or knockout mice indicate a role for IGF-1 in supporting oligodendrocyte survival and FGF2 as an inhibitor of oligodendrocyte progenitor differentiation (Armstrong et al., 2006; Mason et al., 2000; Murtie et al., 2005).

These studies are usually conducted either in vitro using cell culture or in vivo using transgenic rodents, either with knockouts to assess the effect of removing the gene or with knockins to assess the affect of adding the gene.

A study using transgenic vitamin D receptor (VDR) knockout mice reported that the correlation between vitamin D and glucose tolerance was heterogeneous, based on the genetic background of the strains used to make the transgenic mice [ 6].