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The animals were mechanically ventilated using tidal volumes of 10 ml/kg.
Patients were ventilated using tidal volumes of 8 to 10 ml/kg of ideal body weight.
Patients without lung injury at onset of mechanical ventilation were randomized to a conventional protocol using tidal volumes of 10 ml/kg ideal body weight (IBW), or a lung-protective protocol using tidal volumes of 6 ml/kg IBW.
Thus, applying protective ventilation using tidal volumes of around 6 mL/kg [ 104] may also be considered kidney-protective ventilation.
Rabbits treated with intravenous LPS show enhanced lung injury in response to mechanical ventilation using tidal volumes of 10 to 15 ml/kg.
Prior studies demonstrated that mechanical ventilation alone, using tidal volumes of 10 mL/kg, does not independently cause significant cytokine production, neutrophil recruitment, or lung permeability in mice.
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Before consideration of ECMO initiation, all patients were sedated and ventilated with pressure-controlled ventilation using tidal volume of 6 8 ml/kg predicted body weight (PBW).
The second goal was to determine whether lower tidal volumes may be less injurious than the commonly used tidal volume of 10 ml/kg.
We therefore aim to investigate the effects of lower tidal volumes (5 and 7 ml/kg) compared to the commonly used tidal volume of 10 ml/kg without and with addition of PEEP and compared to spontaneously breathing animals in a mouse model of mechanical ventilation.
Mechanical ventilation was provided and the following volume-controlled mode was used: tidal volume of 15 20 mL/kg, respiratory rate of 26 per minute, inspiratory/expiratory time ratio of 1 3, positive end-expiratory pressure of 0 cm H2O, and inspiratory oxygen fraction of 0.3.
It is noteworthy that the type of MV used (tidal volume of 15 ml/kg body weight and positive end-expiratory pressure of 3 cmH2O) for a duration of only 90 minutes did produce marked alterations in the lung and certain distal organs.
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