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Using this study design allows us to see what happens to them with diabetes as well as to see who will develop a new disease.
Using this study design, cyclophosphamide, 1,3-butadiene and urethane have been examined and each compound produced positive responses: cyclophosphamide in all endpoints examined, 1,3-butadiene in some and urethane only produced liver tumours in F1 male offspring.
Indeed we were not able to detect an association of longevity with the J haplogroup using this study design.
Therefore using this study design we minimized possible factors interfering with our measurements.
Using this study design, we did not have the sample size to fully account for all the possible co-morbidities.
However, studies in similar populations using this study design have not shown bias as a result of time (Goodwin et al, 1999).
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Plans are moving forward to use this study design and methods in other critical care settings.
We confirmed the results of another recent study that used this study design in a population based sample from one hospital in Israel, which reported on a composite of hypertension disorders and other complications.
So, we decided to use the average income, because it is one of the most common socioeconomic indicators used in this study design [ 16].
Using this novel study design, we find that CA3 has a less abnormal expression pattern at baseline than CA1, consistent with the observed pathological gradient in susceptibility.
Further studies on this topic using a prospective study design are necessary.
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