Using this scheduling, all the slots and budgets of all bidders will be consumed.
Furthermore, we notice that, although administration of IPTi along with the EPI schedule facilitates logistics, the results using this schedule are far from being optimal in every region.
Using this schedule of administration, fosquidone has no significant antitumour activity in this group of tumours.
To date, we are not aware of the publication of any other phase II prospective study of capecitabine plus irinotecan using this schedule.
Phase II studies using this schedule are ongoing in patients with refractory multiple myeloma, chronic lymphocytic leukaemia and mantle cell lymphoma (NCT01652144 and NCT01627054).
In conclusion, decitabine is difficult to deliver in combination with carboplatin AUC 6 on a 28-day schedule; moreover, in this patient group and using this schedule it definitely does not increase and may decrease the RR to carboplatin.
Results from clinical trials suggest that a 2-, 3-, or 4-mo infant schedule may be acceptable, although further information is needed given the lower immunogenicity that was observed using this schedule.
Using this schedule, different drugs known to be active in NB were used, with the exception of mitoxantrone, whose activity in NB had been demonstrated in vitro (Fulda et al, 1995) but had never been explored in vivo (Kushner et al, 1990; Pinkerton, 1991; Berthold and Hero, 2000).
The MTD for weekly administration of patupilone was determined at 2.5 mg m 2, and in studies using this schedule, the rate of grade 3 or 4 diarrhoea was reported at 19% and 22% (Rubin et al, 2005; Hussain et al, 2009).
We use this schedule of updates and parity checks for the TDMP algorithm (with alternating message-passing and parity-check phases) as a benchmark in the article and refer to it as the TDMP algorithm with the standard schedule.
