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The threshold of the statistical maps was at a voxel-wise intensity of p < 0.001 (uncorrected) with a false discovery rate correction at the cluster level using the whole brain as the volume of interest.
ROIs were drawn manually using the whole brain for 18F-FDG studies and striatum for 18F-fallypride studies.
SUVR and DVR values for the frontal cortex were calculated using the whole brain and cerebellum as denominators.
This will be the case especially when using the whole brain as a denominator, as the target region is included within the reference region.
The validity of using the whole brain versus VOI was demonstrated by Weeks et al. (1997) in a study of Huntington's disease using [C]DPN binding.
For functional scans, significant classifications were obtained both at whole brain level and when restricting the analysis to the fear network while gray matter SVM analyses correctly classified participants only when using the whole brain search volume.
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"You can't just make these decisions using the top of your spinal cord, you have to use the whole brain," said Philip D. Zelikow, the former counselor at the State Department.
We use the whole brain, but there are energies that we cannot yet reason with objectively.
Whole-brain and ventricle BSI were calculated using linearly registered baseline and 12-month scans using the whole-brain and ventricular regions.
The level of FA between the dancers and the control group was examined using the whole-brain voxel-wise comparison analysis (dancers > controls; controls > dancers).
In order to quantitatively assess metabolic changes, cerebral metabolic rate of glucose (CMRglc) were computed from the dynamic PET frames with the non-invasive method proposed by Wu (2008), using the whole-brain as our reference region.
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