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Significant biological pathways were identified using the well annotated GeneGo MetaCore™ database [ 17].
Statistically significant biological pathways were identified using the well annotated GeneGo MetaCore TM database [ 26], which is a commercial tool.
For pathway analysis using the well annotated mammalian genome and proteome databases and tools, the Atlantic cod genes were mapped to human orthologs as described before [ 28].
We retrieved sequences of opsin genes through t-blastn searches in 48 bird genomes [ 17] using the well annotated chicken (Gallus gallus) and zebra finch (Taeniopygia guttata) opsin gene sequences as queries.
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Coding sequences were retrieved from GenBank [ 72] and from genome project databases [ 62, 73, 74] using the well-annotated human sequences for USP4, USP15 and USP11 as tBLASTn queries [ 75].
We demonstrated – using as a reference the well annotated human and mouse genomes – that the observation of clusters of coding CSTs is a good indicator of the existence of a gene locus.
All predicted fox CDS were further searched using BLAST [ 51] in the well annotated human protein database from Ensemble and the non-redundant uniprot database using an e-value of 1e-5.
Current tools (GeneDistiller [14] and Endeavor [15], ToppGene Suite [16]), which incorporate whole gene expression data all use the well annotated but limited discrete datasets like the well known Gene Expression Atlas dataset from Novartis which includes a genome wide expression survey of 40 normal tissues [17].
Our students have created live blogs from the field to record learning and used the Skitch app to annotate images for later use in GCSE classroom sessions.
The development of new metabolic models is facilitated by using previously inserted, well annotated components that were created during prior reconstruction processes.
The multitude of comparative and ab initio gene finding programs that were used to annotate genes in the 11 Drosophila genomes and the use of well annotated D. melanogaster genes during the annotation of the other 10 Drosophila genomes greatly increased the reliability of these annotations [ 78].
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