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We then compared the EQ-5D scores obtained using the unweighted scoring rule with 'official' weighted scores.
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In a separate analysis we used the unweighted scores for Rega.
Individual domains and full-length T. reesei cellulase structures were scored using the unweighted hydrophobic patch score term in Rosetta, as previously developed [ 25, 74].
Two independent reviewers extracted relevant trial characteristics and interobserver agreements were checked using the unweighted-kappa score [ 41]; differences between reviewers' data were resolved by discussion until a consensus was reached.
Pairwise similarity scores for the isolates were calculated by the Dice coefficient, and an overall similarity score was calculated by using the unweighted pair group method with arithmetic mean.
The similarity Z-score matrix was modified into distance matrix in order to infer clustering tree using the unweighted pair-group method with arithmetric averages (UPGMA) of PHYLIP package [69].
In both scenarios, using the unweighted features, the worst results were reached.
Cluster analysis was performed using the unweighted pair group method with the averages algorithm (UPGMA) [ 18].
Individual samples were then clustered within each of the five trees using the unweighted UniFrac method.
Dendrograms were generated using the unweighted pair-group method with arithmetic averages (UPGMA) calculation.
A dendrogram was generated by using the unweighted pair group method with arithmetic averages (UPGMA).
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