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Using the Trim and Fill method, one additional imputable study was identified.
By using the trim and fill method, we showed that, if the publication bias was the only source of the funnel plot asymmetry, it needed seven more studies to be symmetrical (Figure 4).
Publication bias was examined using the trim and fill approach of Duval and Tweedie [ 75].
Finally, we robustly assessed bias using the trim and fill method.
40 If publication bias was present, the effect of such bias on the summary estimate would be assessed using the trim and fill method.
26 We then corrected for asymmetry using the trim and fill method, with adjusted relative risks and the number of studies adjusted presented for each pollutant.
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Publication bias was adjusted using the trim-and-fill procedure.
We decided to adjust for this publication bias using the trim-and-fill method (13).
Furthermore, when looked for missing studies using the trim-and-fill random effects model, no studies needed to be imputed.
Publication bias was evaluated with funnel plots and the Egger's regression test and adjusted using the trim-and-fill procedure.
Bürkner and Doebler [ 27] also suggest using the trim-and-fill method as an option for handling publication bias in meta-analysis when outcomes are binary.
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