Fig. 12 Approval results from the ComplOverlap methodology and with the graphic oracle that used the three extractors and the function χ 2, using the thresholds with α ranging from 1 to 2. The first diagram shows the evaluation results using as references the images manually segmented by individual 1 (G T 1).
Volume Analysis software (Advantage Windows; GE Healthcare, Waukesha, WI) was used to segment and characterize each individual voxel as a tissue attenuation of fat using a threshold range of −190 to −30 Hounsfield units.
In the United Kingdom, NICE uses a threshold range of £20 000 to £30 000 (approximately JPY 2.5 million to JPY 4.5 million) per QALY gained (NICE, 2008), although it is possible that a higher threshold is acceptable for treatments considered under the 'end-of-life' guidance.
In England, for the NHS NICE typically use a threshold range of £20,000 to £30,000 per QALY when determining whether a treatment is cost-effective use of resources.
The analysis was subsequently repeated on a more restricted pool of items those selected for the long scale IONB-QoL through the CTT, and those selected by using a tighter threshold range (0.5÷1.5) considered to be productive for measurement [ 28].
21 For example, NICE formally uses a threshold range of £20,000 £30,000 per QALY, 8 (and in practice, this threshold range may be even higher 21) and formal thresholds for other agencies are not usually published.
The sensitivities using different thresholds range from 0.41 to 0.63.
3– 5 Additionally, the Slovak Republic uses a threshold ranging from Euro 18,000 26,500 per QALY for drug reimbursements.
Appropriate gain and black-level settings were determined on control tissues stained with secondary antibodies alone; upper and lower thresholds were set using the range indicator function to minimize oversaturation in positive cells.
Upper and lower thresholds were always set using the range indicator function to minimize data loss through under or over saturation.
