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The estimation was performed in R using the strucchange package.
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Structural changes (SC) in rural and urban time series were detected using the breakpoints function of the strucchange package, in R v2.9.1 software.
The statistical analysis were performed using the R statistical package and the effsize package (Torchiano 2017).
Models were fitted using the lme471 package.
Solubility and supersaturation were calculated using the software package EQ3/6.
Data were analyzed using the R package.
This was completed using the software package Neuralog.
MBO is performed by using the R package mlrMBO [64].
Problems are solved using the software package "LINGO".
Analysis was done using the same package.
and R using the lumi package [ 27].
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