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The survival difference between the three response curves tended to reach statistical significance using the strict method described by Rubbia-Brandt et al (2007) when applied on the worse nodule (P=0.063, Figure 2F).
This study found that (1) the analysis of all the nodules using the strict method described by Blazer et al (2008) was not significantly discriminant with respect to patient survival and (2) the analysis of the nodule with the worse response using the strict method described by Rubbia-Brandt et al (2007) tended to reach statistical significance but was no more performant in this study population.
In conclusion, PR based on analysis of the worse nodule using the strict method described by Rubbia-Brandt et al (2007) or all the nodules using the strict and the modified method by Blazer et al (2008) (i.e., mean and median of the responses, respectively) did not significantly predict the cumulative survival rate in our series.
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A single technician assessed sperm morphology using the strict morphology method, as recommended by the WHO (1999).
The approach of the latter, in contrast, is to find all trees of optimal score and to summarize them using the strict consensus method into a potentially multifurcating supertree.
A conservative approach using the "strict" tree-based method should be used initially in large-scale identification systems.
For a set of 13 gamma proteobacetria 236 gene families were assembled using the strict reciprocal top scoring BLAST hit method (see Methods for details).
236 families of putatively orthologous genes were detected using the strict reciprocal best Blast hit method [ 46, 47, 51, 52] with an E-value cutoff of 10-4.
TMRCA of P. vivax was estimated using the strict-clock Bayesian MCMC method as implemented in BEAST v1.5.4 [ 44] with non-coding region of the mitochondrial genome.
For this correction, we used the strict false discovery rate (FDR) method described by Benjamini and Yekutieli [ 39], Hypothetical auto-regulated TTSs are those that appear in transcribed and promoter (200 nts upstream) regions of two distinct genes.
Note, we use the strict interolog definition for two species and the relaxed criterion for multiple species (see Methods).
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