Exact(1)
To determine specific pathways, gene pathway analysis were conducted using the Genego program available at http://trials.genego.com/cgi/index.cgi using the statistical significant ANOVA gene list (p<0.05, fold change>1.5) represented on the chip.
Similar(59)
For continuous outcomes, standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated as the differences in means, and α = 0.05 was used as the statistical significant level.
Treatments in Experiments 1 and 2 were compared by analysis of variance and least significant difference (LSD) using the statistical program Statistix 9 (Analytical Software, USA).
Student's t-test was used to assess the statistical significant differences in the results.
The Cox proportional hazards regression model was used to determine the statistical significant of the variables related to survival.
Two-tailed Student t test was used to assess the statistical significant differences between means of the two groups at 3, 6, and 9 months, separately.
As the number of features was large, F-statistic [ 25] was used to find only the statistical significant features for classification.
All data are present as the mean ± S.D. Unpaired Student's t test and one-way ANOVA were used, as appropriate, to assess the statistical significant of differences between two groups and three or more groups respectively.
Using Kolmogorov Smirnov, no statistical significant difference was found between the patients that were rapid cycling and patients that were not (p = 0.656, see Fig. 2).
We then performed statistical analysis using the significant analysis of microarray (SAM) package [ 49].
The paired or unpaired t test (two-sided) was used to test statistical significant differences of normally distributed results, and the Mann-Whitney-U-test was used when normality requirements were not met, with p < 0.05 considered in both cases as statistically significant.
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