Because each of these studies only provided a list of genes but no mathematical formula for predicting response from these genes, each classifier was re-trained on the four whole blood data sets using the specified genes and same clustering method specified in the original studies.
The concentration of each drug was calculated using its specified methods.
(ii) Determine the relative proportions of biogenic and non-biogenic CO2 emissions in the flue gas on a quarterly basis using the method specified in § 98.34 d) (for units that combust MSW as the primary fuel or as the only fuel with a biogenic component) or in § 98.34 e) (for other units, including units that combust tires).
Frailty was defined by calculating a frailty index from the accumulation of deficits in interRAI Home Care domains (including cognition, communication, mood, functional status, continence, health conditions and symptoms, nutritional status, and number of medications) using the method specified by Rockwood [ 8].
HEK 293T cells were plated on cover slips and transfected with different constructs using the methods specified above.
Evaluation of sample size and follow-up jointly showed that all 3 cohort studies using administrative data exceeded the requirements of the guidelines for pre-approval safety assessment, whereas this was the case in less than a quarter of the studies using any of the other specified methods (Table 3).
ftol - the function tolerance to terminate the search for the minimum, using the optimization method specified in the method parameter.
maxfev - the maximum number of function evaluations using the optimization method specified in the method parameter; default is 'None'.
Power and sample size calculations were based upon simulations for change from baseline in DAS28 at all assessed postbaseline visits, using the MMRM method specified for the primary efficacy analysis.
Using the protocols specified in the methods, the J774A.1 macrophage cell line monolayers were prepared and incubated with r-GV then fixed as described at the different, specified times and stored at -20°C for subsequent assessments.
Prediction of putative target genes was assessed by miRanda using the parameter specified in the Methods section.
