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Despite the lack of any evidence of adverse effects after MR studies in the human foetus [25], gadolinium-based contrast agents are classified as category C drugs by the FDA and should only be administered to a pregnant patient "if the potential benefit justifies the potential risk to the foetus and using the smallest dose of the most stable gadolinium agent" [26].
Most experts currently recommend using the smallest dose that achieves the desired clinical effect, avoiding booster injections, and waiting at least 3 months between treatments.
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Use the smallest dose that you find to be effective.
As a result, nephrologists must tailor ESA therapy to the patient's profile by using the smallest possible dose to control anaemia symptoms and achieve Hb target level.
In order to prevent crystallization by the electron beam, the samples were examined under low electron-dose illumination using the smallest condenser lens aperture (10 μm).
While it is desirable to use the smallest possible contrast dose resulting in adequate image quality, to avoid problems such as volume overload and contrast agent toxicity 24, 25, injection of small doses is limited by the dead space within the catheter lumen and inconsistencies in measuring very small contrast doses.
Our vet suggested using a smaller dose in the tranquilliser dart, so she could still walk.
8 A small trial using the much lower dose of 4 mg three times a day suggested benefit in IBS and functional dyspepsia.
Because a higher control rate is typically obtained for smaller tumors using the same radiation dose, response to radiotherapy (CR+PR) for central ICC was better than peripheral ICC (central ICC, 58.3%; peripheral ICC, 26.1%; P = 0.061).
The small doses used for eye disease seem to be safe, but these agents are very potent.
Therefore, each drug's therapeutic action is enhanced while the adverse effects of each are minimized because of the small doses used.
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