Sentence examples for using the significant snp from inspiring English sources

The MEBV was calculated using the significant SNP effects in Table 2 and polygenic effect calculated using the pedigree information.

Breeders may also use the significant SNP markers we have provided to design assays for possible marker assisted selection or screening of resistant materials in their own breeding programs.

Considering that the phenotype variability is more likely associated with SNPs assembled in haplotype configuration rather than singularly, an additional analysis was performed with haplotypes, inferred by FastPhase [ 48] using only the significant SNPs.

A conditioned analysis was performed using the most significant SNP, MARC0033464, as a fixed effect.

Variant Effect Predictor (VEP) from Ensembl website was used to verify if the significant SNP was near a gene and determine the distance.

Using the most significant SNPs may not increase prediction either.

For peaks that reached the Bonferroni threshold, the genomic region was explored by inspecting a 100kbp window surrounding the location of the significant SNP using ovine genome v 3.1 (available at Ensembl http://www.ensembl.org/Ovis_aries).org/Ovis_aries

Additionally, we explored the different options to define gene-wise P values, including the VEGAS-all method, which built on all the SNPs mapped to a gene, the VEGAS-top method, which used the top 10% SNPs mapped to a gene, and the minP method, which used the most significant SNP.

The function of the significant SNP was evaluated using luciferase reporter assays in two cell lines.

Although this gene was not annotated in cattle, by comparative analysis we were able to locate the gene on the region of BTA9 where the significant SNP was located using the similarity with the human ortholog.

After quality control filtering, a Monte-Carlo simulation was used to rank the significant SNPs according to the ratio of allele frequencies and the coefficient of variation.