The revised BESO method includes a filter scheme, an improved sensitivity analysis using the sensitivity history and a new procedure for removing and adding material.
We assessed vitamin D in serum, fasting blood glucose, serum insulin and glycosylated hemoglobin (HbA1c) levels and we depicted the insulin sensitivity using the Quantitative insulin sensitivity check index (Quicki).
The sensitivity of interior equilibrium Ê with corresponding parameters is analyzed using the normalized forward sensitivity index, and the sensitivity of parameters is shown using the bar graph (see Figure 11).
The PCA based method does not use the sensitivity matrix S, but a sensitivity matrix is calculated for each component r i of the response function separately.
Insulin sensitivity was estimated using the Matsuda Insulin Sensitivity Index (ISI), and β-cell function was estimated using the Insulinogenic Index.
Insulin sensitivity was quantified using the Matsuda insulin sensitivity index for oral glucose tolerance tests (ISOGTT) (9), and IR was measured using the homeostasis model assessment of insulin resistance (HOMA-IR) index (10).
Insulin sensitivity was assessed using the Matsuda insulin sensitivity index (ISI) for OGTTs (27), calculated by dividing 10,000 by the square root of the products of fasting glucose and insulin and the average OGTT levels of glucose and insulin.
Insulin sensitivity was assessed using the composite insulin sensitivity index according to Matsuda and Defronzo, calculated with the following formula: 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during OGTT] (12).
Insulin sensitivity was estimated using the quantitative insulin sensitivity check index (QUICKI) obtained from fasting baseline determinations (18) and calculated as the logarithm and the reciprocal of the insulin-glucose product: Alcohol consumption was calculated as units of alcohol (glass of wine = 20 units, glass of aperitif = 30 units, and glass of liquor = 80 units).
When the insulinogenic index was normalized for insulin sensitivity using the whole-body insulin sensitivity index, the groups were identical in their β-cell response (insulinogenic index/whole-body insulin sensitivity index = 0.21 ± 0.19 vs. 0.21 ± 0.13 for those with and without abdominal obesity, respectively).
Thus, adjusting insulin secretion for the level of insulin sensitivity using the disposition index (insulin sensitivity × β-cell function) may be a better measure of β-cell function (20).
