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A receiver operator characteristics curve (ROC curve) was constructed using the sensitivity and specificity of each maneuver extracted from included study using Meta-DiSc version 1.4 (Universidad Complutense, Madrid, Spain) [35].
This report clearly demonstrates the critical importance of reference gene validation for all experimental conditions regarding significance, interpretation, and experimental outcome when using the sensitivity and reliability of qRT-PCR for assessment of relative gene expression.
Likelihood ratios for MODY were calculated using the sensitivity and specificity obtained from various cut-offs in fitted probabilities in the models.
Using the sensitivity and specificity obtained through the ROC-curves, the Youden index, which corresponds to the maximum vertical distance between the ROC curve and the diagonal line (Schisterman et al., 2005), was calculated.
Two or more diagnostic tests can be compared with each other: using the sensitivity and specificity of the different imaging modalities, the probabilities to be accurately diagnosed with corresponding optimal treatment can be assessed in the decision tree model.
Basic modelling, using the sensitivity and specificity of the HRP-2 RDT gained from a Cochrane Review (Abba 2011), predicts that areas of low malaria transmission have the greatest potential for health benefits as a result of introducing RDTs, and the lowest potential for harm from false negatives (see Figure 1).
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When a dysplasia index threshold of ≥2 was used, the sensitivity and specificity for diagnosing IMC/HGD were 83% and 75%, respectively.
We then applied the NDSS definition to the entire random sample and used the sensitivity and specificity estimates to adjust prevalence estimates.
In contrast, when the new cut-off value was used, the sensitivity and specificity for SLE were 21.0 and 1000%, respectively (Table 1).
We used the sensitivity and negative predictive value (NPV) to evaluate the performance of PAM50 as a binary classifier of risk of relapse.
When the recently proposed cutoff point of 6.0% for the screening of individuals at high-risk of diabetes (5, 6) was used, the sensitivity and specificity were 56 and 97%, respectively.
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