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Proteinuria is the direct result of renal damage, the severity being assessed histologically by a board-certified pathologist using the scoring method outlined in the Methods and Material section, as described by Senuma et al. [ 21].
The number and severity of erosions were scored using the scoring method as follows: 0 = No lesion, 0.5 = Hemorrhage, 1 = 1 3 small lesions < 10 mm length, 2 = 1 3 large lesions > 10 mm length, 3 = 1 3 thickened lesions, 4 = more than 3 small lesions, 5 = more than 3 large lesions, 6 = more than 3 thickened lesions [ 9].
The BaP doubling dose for the Pig-a endpoint in RET could not be calculated using the scoring method used for this study since no RETCD24− were detected in unexposed control animals in this study, and a measurable level of background mutant Pig-a phenotypes is required to calculate doubling dose (see Eq. 1).
Using the scoring method described above for CCND1 staining, 48% of samples in the sensitive group were graded as '-', 28% as '+', 16% as '++' and 8% as '+++'; while only 20% in the resistant group were graded as '-', 24% as '+', 44% as '++' and 12% as '+++'.
These personal events were scored by two raters using the scoring method described by Westmacott et al. (2001) and that reported by Graham and Hodges (1997).
We tested the HMMs generated by all the approaches by scoring them on known sequences using the scoring method described next.
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We have computed 95% confidence intervals for the sex ratios using the score method (3, 4).
The 95% CIs for binomial proportions are presented using the Score method [ 32].
Haplotype association was analyzed using the score method of Schaid et al. (37) with adjustments made for age and gender.
Where appropriate, 95% confidence intervals (95 CI) for proportions were computed using the score method with continuity correction.
The primary outcome measure for this study is the proportion of residents using sleep aids, 95% confidence intervals of this proportion have been computed using the score method with continuity correction.
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