More promising is to use the score approach to select SNPs for use in complex modeling of the trait for instance to study gene by gene interactions which otherwise seems impossible with 2.5 million SNPs.
The 95% confidence intervals (CI95) for binomial probabilities were computed using the score-test-based approach of Wilson (Agresti and Coull, 1998).
On the other hand, the average percent rank of the true DAG using the likelihood scoring approach was 2.28%, implying that the true DAG was ranked as approximately the 670th best scoring DAG on average.
Comparison of ROC curves for the AuPosSOM and four conventional scoring functions revealed that for eight out of nine targets, the results yielded by AuPosSOM are as good as (or better than) the results obtained using the energy scoring approach.
Since scoring a '3' on the descriptive system of EQ-5 D is related to the problem of overprediction, we took an alternative approach using the scores on the condition-specific measure that correspond to having at least one level '3' response.
All score functions are standardized through (11) and calculations are performed using the NPL score approach (12).
The effect on outcomes of various therapeutic analgesic options administered by physicians, given the observational approach where patients are not assigned at random to different treatments, will be compared using the propensity score approach, allowing the adjustment for treatment selection bias.
Since waist-to-hip ratio can be a proxy measure of intra-abdominal fat deposition, we examined its effect on the association using the polygenic scores approach in the UK Biobank.
Given the observational setting, outcomes of subjects who were not assigned at random to different treatments will be compared using the propensity score approach, allowing the adjustment for treatment selection bias [ 20], as recently done in some large observational population studies [ 21, 22].
Using the Z-score approach for testing individual infants, the response at P8 is also significant for the individual data of 7 infants out of 15 (ps < 0.05, Z-score > 1.64 for signal vs noise computed over neighboring frequency bins, see 'Materials and methods').
