Figure 1 illustrates the difference in the convergence of normalized innocent user scores to the standard normal distribution, when using the score functions g and h.
What about comparing the score of the alignments using the score functions reported by state of the art MSA algorithms?
The azaheterocycles that coordinate with the heme iron were identified using the scoring function (Eq. 1) and subjected to analysis of the nitrogen heme iron coordination.
The selection operation enables the individuals with higher fitness which is evaluated using the scoring function to be preserved with greater probability, so that the population converges to the global optimum at the fastest speed.
Using the scoring function (Eq. (9) of Methods), we address the question of interaction specificity for TCS proteins extracted from the genomic library.
For simplicity, fold recognition or template-based modeling by using the scoring function with 5 terms is called FR-t5, while the method that uses the scoring function consisting of the three terms, sequence profile, secondary structure, and hydrophobic score is denoted as FR-t3.
For each parameter, a formal test for outliers was performed using the "scores" function in R, with a probability of p = 0.99 used as a threshold.
The execution of MetaID involves the following steps: model building using the scoring function, identification of genomes in the metagenomic reads and obtaining their abundance estimates.
The results demonstrate that the AuPosSOM contact analysis followed by scoring of the compounds using the scoring function developed can provide a high level of selection for active compounds.
