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A general linear model (using the SAS command PROC GLM) was used to determine interaction in effects of genotype on baseline measures and on change from baseline to 12 months.
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The primary analysis (sequential test) was performed using the SAS software (SAS® software, version 9.2, for Windows (SAS Institute, Cary, NC, USA)).
The statistical analyses were done using the SAS-Enterprise and SAS-JMP software.
All further analyzes were conducted using the svy command.
The analysis was performed using the MCM command UAMCM.
The time measurement was obtained using the Unix command 'time'time
We analysed the imputed data using the micombine command [ 29].
Normality was visually inspected using the "normplot" command in Matlab.
These estimates were obtained from PLINK, using the "–het" command.
Weighting was applied using the 'ccode' command in TNT.
We combined these using the MIcombine command in STATA.
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