An ICC of 0.7 or higher was deemed acceptable [ 25]. 1 The standard error of measurement (SEMagreement) was calculated using the same variance components used for the ICCagreement calculation (equation 2) [ 26], comparing the NL T0 with the NL Ts data. 2 Construct validity In order to evaluate construct validity the 'hypotheses testing' method was chosen in absence of a gold standard [ 27].
Using the same variance analysis as performed for the 163 disease-genes, only 60.0% of ClinVar genes met our criteria for being clinically interpretable, and this improved to 98.6% when restricting the analysis to LoF PPVs (Fig. 2A and B) and averaged 7.8 LoF PPVs per individual.
If the gene is DE, we use the same variance but different mean as that of the control group.
To summarize, we used the same variance in the non-control group as that in the control group.
A further limitation is that we use the same variance to generate each within-grid time-series and that time-series, both modelled and monitored, are simulated without seasonal pattern or trend.
For non-pleiotropic QTL, α BN and α BW were drawn from normal distributions using the same QTL variances as for pleiotropic QTL.
The analysis comparing how quickly different pairs of morph levels converge is shown in Figure 5 b, using the same analysis of variance used in Figure 5 a, but comparing other pairs of morphed stimuli (Supplementary Fig. 3 c ).
Using the same approach, the variance with brain pH was found to be due to the tissue from the MDD_suicide group being higher than for the control (p<0.01) and schizophrenia_suicide (p<0.01) and schizophrenia_non_suicide (p<0.001) groups (Additional file 2: Table S2).
We also compared BBGP to the standard GP of Kalaitzis and Lawrence (2011) that does not use the FBB model variances using the same replicate combinations as BBGP with 6 time points.
The equation for the model was as follows: Y: Bottom + (Top − Bottom)/[1 + 10^(X − LoglC50)], where Y is % inhibition, Bottom is the lowest value of % inhibition, Top is the highest value of % inhibition, and X is Log ligand concentration IC50 values were analyzed by ANOVA (Analysis of Variance) using the same program.
