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All infants were transfused using the same transfusion triggers and with a similar RBC blood product with only a different volume per event, i.e. 15 and 20 ml/kg bodyweight.
Brodie et al. recommend using the same transfusion thresholds as those used in the care of patients with ARDS who are not being treated with ECMO [ 3].
We previously published a study comparing two transfusion dosages of the same RBC product in two Dutch tertiary care neonatal units (NICUs) using the same transfusion trigger protocols [ 2].
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During the study period, we used the same transfusion thresholds for both pRBCs and PC and/or IVIG.
The two Dutch NICUs participating in this study used the same transfusion guideline, transfusion trigger and transfusion product, which virtually excludes important differences in degree of anemia between infants.
Following the blood transfusions, we reevaluated Hb levels at 6 hours after the end of the transfusion period, and blood replacement was considered again using the same criteria as outlined above.
Iron overload can be measured in NTDT patients using the same techniques as for patients with other types of iron overload, including hereditary hemochromatosis or transfusion-related iron overload.
A Cox regression model, using the same covariables, was used to analyze the adjusted PICU length of stay and the time between the first transfusion and development of the primary outcome.
Regrettably, despite both groups were managed using the same clinical protocols, as far as other interventions that might affect the microcirculation were not computed (such as red blood cell transfusion), we cannot attribute this improvement to DrotAA therapy.
Using the same experimental design as the pilot study described above, 838 critically ill patients were randomly assigned to a restrictive or liberal transfusion strategy.
Thus, it may be acquired from a blood transfusion or from being inoculated with a contaminated needle used by another person (e.g., among drug addicts using the same needle).
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