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To prove explicitly that our stimulation activates hilar cells, we stimulated the MML using the same stimulating electrode position, intensity, and train duration/frequency as shown in the manuscript and assayed hilar neurons with cell-attached and current-clamp recordings (n=4 cells).
Previously published literatures of acute studies on few subjects have shown contradictory evidence on the reproducibility and characteristics of the elicited phosphenes, despite using the same stimulating parameters with epiretinal electrode arrays.
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In the next step, using the same model of TNFα-stimulated HAECs, we compared the inhibitory effect of A. Melanocarpa extract on pro-inflammatory responses in endothelial cells with those of other drugs with well-known anti-inflammatory and/or anti-oxidant activities.
Using benchmark dose (BMD) methodology, the results for each tissue were also compared for both the individual laboratory and the pooled data from all laboratories using the same test substance and, where applicable, the same stimulating TP dose.
However, these studies lacked the comparison to healthy controls, whereas another study by the same group using the same methodology found increased luminously stimulated occipital blood flow in migraine patients interictally with and without concomitant painful stimulus compared to healthy controls [ 37].
Interestingly, using the same methodology, we documented that rapamycin stimulated autophagy in both cell types, under normoxia and hypoxia.
However, when using the same specific antigens, the ability to stimulate CD8 T cell proliferation through different immune formulation was better in the F + A + R, F + A + P, and especially in the F + A + R + P groups.
When repetitively stimulating the neurons using the same random conductance waveforms as artificial synaptic inputs, one can assess the reliability and precision of their firing [20], [21], [22].
The result is an experience that stimulates multiple senses using the same patterns.
This is not surprising as Rise et al. [ 22] obtained similar QPCR results for TLR3 (using the same primer pair) in spleens from cod stimulated with pIC.
These substances are presumed to stimulate the taste receptors using the same receptor proteins as sugars.
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