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A Japanese multicenter phase III trial using the same regimen has also shown favorable results consistent with the result of ABC-02 study: the median survival and overall response rate of GC vs. GEM alone were 11.2 vs. 7.7 months and 19.5 vs. 11.9%, respectively [6].
Recently, a response rate of 34% was reported in a multicentre study, using the same regimen (Nowak et al, 2000).
This measure is unlikely to have differentially influenced the malaria data because both plantations were using the same regimen.
This study was conducted after a phase I trial using the same regimen of ziv-aflibercept/cisplatin/pemetrexed (Diaz-Padilla et al, 2012).
In the phase I study using the same regimen (N=18), five patients experienced a mild neurocognitive disturbance but no RPLS was diagnosed (Diaz-Padilla et al, 2012).
Similar high rates of grade 3 and grade 4 neutropenia and gastrointestinal adverse events were reported in other clinical trials using the same regimen [ 7].
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Group 3 (n=8) received both gossypol and TMZ treatments using the same regimens as above.
That difference might be explained by the relatively low disease incidence rate in Japan since treatment achievements from using the same regimens are similar in Japan and other developed countries.
Troxacitabine was administered intravenously (IV) at 1 and 5 mg/kg q3d × 4 and gemcitabine was administered intraperitoneally (IP) at 80 mg/kg q3d × 4. In the combination studies, drugs were injected sequentially using the same regimens (troxacitabine first, followed by gemcitabine 1 h later; gemcitabine first, followed by troxacitabine 1 h later).
Another report, which used the same regimen but only in patients with genotype 1b infection, achieved SVR 90% [ 46].
Hensley et al. used the same regimen as second-line treatment for patients with advanced uterine LMS [ 24].
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