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In the present study agreement was estimated using the repeatability coefficient.
In the 800-mg cohort, the median PFS among the metabolic responders using the repeatability coefficient threshold of at least a 34% reduction in SUVmax was longer than median PFS among metabolic nonresponders on both days 15 and 56, although the difference was less pronounced on day 15.
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Agreement between gait parameters measured within the same day (session 2 and 3) and between days (session 1 and 2; 1 and 3) were evaluated using the 95% repeatability coefficient.
We compared the quantitative metrics produced by this framework with some of the widely used proprietary software using Bland Altman analysis and the repeatability coefficient (RPC) for the framework was 5.3, with the intraobserver RPC being 4.5.
The repeatability coefficient used as the statistical estimate of test-retest precision in this study can be considered a conservative measure but is in line with results from studies of FDG-PET [16].
Based on the repeatability evaluation in this study, metabolic response was determined using both the EORTC threshold and the repeatability coefficient threshold of at least a 34% reduction in SUVmax.
Reproducibility was assessed using the concordance correlation coefficient (CCC) and the repeatability coefficient (RC) (95% confidence interval [CI] range).Mean peak twist measurements were 13.4 ± 4.3° (day 1, scan 1), 13.6 ± 3.7° (day 1, scan 2), and 13.0 ± 2.7° (day 8).
Results: The repeatability coefficient (RC) of PVBC and NME was 20 % and 0.34 cm H2O/uV respectively.
Bland and Altman recommend estimating the repeatability coefficient [ 29].
The repeatability coefficient for exploration behaviour was calculated [ 46].
The repeatability coefficient is defined as two times the SD of the difference between the measurements.
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