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Here, we examined autoantigenic citrullinated proteins in a synovial tissue sample from a patient with RA by using the proteomic approach and then investigated the contribution of citrullination to autoantigenicity on one of the identified autoantigens, CapZα-1.
More than 60 putative EHEC type III effectors have been proposed using the proteomic approach [39] and bioinformatic studies [40].
These enriched datasets were built by retrieving and integrating distributed genomic and proteomic DAS sources using the API.
The enzyme production in a non-lignocellulosic medium (CSS) under SmF culture conditions was studied at long incubation times (21 d) mimicking N- and C-limitation, using the same proteomic tools applied for SSF secretomes.
The UniFrac diversity metric was applied to the sub-sampled viral OTU table using the Phage Proteomic Tree.
We produced proteomic data using the ENCODE Tier 1 cell lines K562 and GM12878.
The signaling interactions within each proteomic cluster are extracted from the Pathway Commons 2 database using the PERA algorithm.
If one needs to create a custom array or selected proteins for targeted quantitative proteomic analysis using the selected reaction monitoring (SRM) assay, one can use GLAD4U and review the ranked list of genes that likely should be included in the experimental design.
The quadrupole ion trap mass spectrometer (LTQ) used in the proteomic analysis was manufactured by Thermo (Palo Alto, CA, USA).
Proteomic features were further analyzed using the significance analysis of microarrays (SAM) software from Stanford University.
We used the high-throughput proteomic technique PICS (Proteomic Identification of protease Cleavage Sites) to comprehensively assay 9 different MMPs.
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