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An estimate of total SIR was calculated using the pooled results from Europe/Canada and the USA.
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This has been the major limitation of other studies and consensus, which have used and pooled results of studies using an heterogeneous set of definitions that preclude and bias pooled results and conclusions [ 15, 16].
Rather than arbitrarily choosing single studies to inform parameter estimation, we used decision rules to pool relevant data: when the data were sufficiently homogeneous we pooled results using the random effects method of Der Simonian and Laird.
§ Pooled results using the random effects model with including the results of the two unpublished trials [5,16].
On the other hand, if a two-stage approach is used, we suggest that the meta-analytic technique used to pool results should be stated explicitly.
Mplus software for Windows (V.7.2) was used to generate imputed data and PROC MIANALYZE from SAS/STAT software (V.9.3) was used to pool results and analyse the imputed data sets.
Dichotomous data (response rate/adverse events) were summarised using relative risks and 95% CIs with the Mantel–Haensel method used for pooling results across trials (Deeks et al, 2001).
Random-effects, method-of-moments models that incorporate heterogeneity into the overall estimate were used to pool results for FN and LS BMD as well as secondary outcomes from each study [ 64].
For all ES's, the beneficial direction of effect was the natural direction of benefit, (for example, negative values for decreases in BMI z-score, positive values for increases in maximum oxygen consumption, etc).. Random-effects, method-of-moments models that incorporate heterogeneity into the overall estimate were used to pool results for BMI z-score and secondary outcomes from each study [ 49].
The meta function in R.v.3.0 was used to pool results and produce forest plots.
Random effects meta-analyses were used to pool results from individual studies.
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