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Genome wide significance thresholds of 5% for the Logarithm of Odds ratio (LOD) values were determined using the permutation command within MapQTL (van Ooijen, 2004).
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Use the Switch command to do that".
For the group analysis, we used the permutation tool "randomise" with 5000 permutations (Nichols & Holmes, 2002).
We used the permutation test (1000 permutations) to estimate P-values.
Empirical P-values were derived using 1000 permutations using the incorporated permutation feature of WebQTL.
The analysis was performed using the MCM command UAMCM.
We analysed the imputed data using the micombine command [ 29].
The time measurement was obtained using the Unix command 'time'time
Weighting was applied using the 'ccode' command in TNT.
Normality was visually inspected using the "normplot" command in Matlab.
These estimates were obtained from PLINK, using the "–het" command.
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