Sentence examples for using the pedigree structure from inspiring English sources

Genotypes were screened for Mendelian errors using the pedigree structure (14).

Individuals were generated using the pedigree structure of the original three-generation intercross (Kerje et al. 2003).

To assess the sensitivity and specificity of CCH to accurately determine the maximum number of individuals IBD at a locus within a pedigree, Monte Carlo genome-wide gene-dropping simulations using the pedigree structure shown in Figure  4A were performed using Merlin [ 20] and repeated 100 times.

We used the pedigree structure of our sample and the trait inheritance model exhibiting the observed familial correlations, but assuming no effect of the tested marker on the trait variation.

Using information on the pedigree structure, mode of inheritance, affection status, penetrance and availability of genotype data, simulation studies can be used to obtain the expected MLOD (EMLOD) and MLOD scores for each pedigree.

Allele frequencies were calculated using the pedigree base population, that is, the 1020 individuals in the pedigree with unknown parents.

At least in domestic animals, the explicit use of the pedigree structure in may be more appropriate to detect genomic regions responsible for recent selection e.g. [ 57, 58].

To evaluate the correctness of our approach on big pedigrees, we generate simulated datasets using the same pedigree structure and missing pattern.

Peddrift [ 11] is a program that also uses single markers to calculate exact probabilities of allele frequency differences, by using the recorded pedigree structure to take into account minor allele frequencies, genetic drift, founder and sampling effects.

Sanger sequencing of all coding exons of TMC1 identified the c.1114G>A (p. (Val372Met)) variant within TMC1 and confirmed co-segregation of this variant with HI in branch 2. Using the entire pedigree structure of family 9, a LOD score of 1.65 was observed although the MLOD score was 6.27.

The Pedigree RElationship Statistical Test (PREST) was used to verify the pedigree structure and detect relationship misspecification.