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Rather than using the parent of the yeast deletion collection, which has a number of auxotrophies, we used a different version of S288c with only a single auxotrophy (YJF173, Table S1).
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A potentially large source of false negatives was our stringent filter to eliminate any genes showing evidence of noncomplementation in the control crosses generated using the parents of the deletion collection.
Research diagnoses of ADHD and psychiatric comorbidities were ascertained using the parent version of the Child and Adolescent Psychiatric Assessment (CAPA) [ 35], a semi-structured interview.
Pain catastrophizing was assessed using the parent version of the Pain Catastrophizing Scale (PCS-P) [ 23].
Behavioral problems were assessed using the parent version of the Strengths and Difficulties Questionnaire (SDQ) (Goodman 1997).
At 2 years corrected age, cognitive development was assessed using the Parent Report of Children's Abilities-Revised (PARCA-R).
ADHD core symptoms were reported by parents using the parent form of the Clinician's Manual for Assessment by Russell A. Barkley.
The impact of the programme on OCD-related functional impairment will be measured using the parent report of the Child Obsessive-Compulsive Impact Scale Revised (COIS-R).
Symptom severity was assessed using the parent version of ADHDRS-IV and parents are likely to evaluate behaviours occurring outside school hours.
ADHD diagnosis was determined using the parent version of the Anxiety Disorders Interview Schedule for Children (A-DISC [ 27]) according to DSM-IV criteria [ 1].
Therefore, STRP alleles are referenced to allele sizes for standard DNA templates (we use the parents of CEPH family 1331 available from the NIGMS Human Genetic Cell Repository).
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