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Based on review of these data along with safety information by the Independent Data Monitoring Committee and the Steering Committee, the study was continued without change using the originally calculated sample size.
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If the conditional power was greater than 80% at the interim analysis then we used the originally calculated n t as the final sample size (n 2 = n t ) so that the final sample size was only altered to increase the conditional power to 80%.
The unfolded result was found much softer than the originally calculated spectrum at the design stage.
3) The originally calculated critical mutation rates underestimate their real values.
Data were grouped by sex, age, residence and initial positive screening, and prevalence figures were calculated by disability level both for the general population, using the originally designed weights, and for the population that had screened positive to disability.
The 11 comorbidities in the above equation, which were originally calculated using inpatient and outpatient claims data occurring anytime within 12 months before an index PE event, were calculated only on the basis of the maximum of 25 ICD-9-CM diagnosis codes and procedural codes reported for each discharge in the NIS.
The CEA originally calculated a 0.1 percentage point loss every two weeks.
The BEA originally calculated these values based on what are called "regional price parities," which measure differences in prices for goods and services between regions.
A mutation rate has not been calibrated for any Accipitridae species, so we used a range of mutation rates originally calculated for the control region in grouse [4.54 12.54% [average 7.23%] divergence per million years, 87]which is similar to that found for the most variable part of the control region in diving ducks [8.8%, 88].
As these rates of nonsynonymous substitutions were originally calculated using orthologous sequences from only 26 mammalian species, we wanted to start by reassessing this issue using a more comprehensive collection of sequences from 371 mammalian taxa.
GEP70 risk scores are calculated using the method originally described by Shaughnessy et al. [ 6], with the additional modification of scaling the score to a range of 0 to 100 to assist in interpretation.
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